TITANIUM IMPLANT MODIFIED BY PLASMA ELECTROLYTIC FOR NEOINTIMA FORMATION IN BLOOD PUMPS
Rosa Corrêa Leoncio de Sá1; Gláucio Furlanetto2; Nilson Cristino da Cruz3; Evandro Drigo2; Tarcisio Leão1; Juliana Leme2; Jeison Willian Gomes da Fonseca2; Bruno Utiyama2; Edir Leal2; Aron José Pazin de Andrade2; Eduardo Guy Perpetuo Bock2
1 Institute Dante Pazzanese of Cardiology and Federal Institute of Technology in Sao Paulo; 2 Institute Dante Pazzanese of Cardiology; 3 Technological Plasma Laboratory of UNESP- Sorocaba
doi:10.20906/CPS/COB-2015-1100
Resumo
Institute Dante Pazzanese of Cardiology, Federal Institute of Technology in Sao Paulo and Adib Jatene Foundation have developed a Ventricular Assist Device (VAD) for patients with severe heart failure. The Implantable Centrifugal Blood Pump (ICBP) is a VAD basically made of Titanium (Ti+4), an important biomaterial with low density and good corrosion resistance. However, when in continuous contact with blood, the released ions can compromise homeostasis and VAD biofunctionality. We are using Plasma Electrolytic Oxidation (PEO) in Ti samples to texturize their blood contacting surfaces. The micro-arcs covered the samples in electrolyte solution (magnesium, sodium phosphate, glycerol and water) for 50 seconds. Current density was maximum of 1.5 A/cm2, under voltage of 500 V. Scanning electron microscopy revealed the formation of uniform and homogeneous pores. Energy dispersive spectroscopy indicated greater incorporation of magnesium. Contact angle measurements showed a significant hydrophilic character of the surface. Preliminary results showed good blood interaction with treated surface under continuous and laminar flow, as there is in ICBP. Implants made of Ti with plasma treated surface are being developed and will be submitted to In Vivo experiments to prove the formation of coating-endothelial living cells with high resistance to thrombus formation.
Palavras-chave: VAD; titanium; surface modification; plasma electrolyte