Assessment the change on rhythm cardiac produces by the metabolic syndrome in rats: using nonlinear methods
Alondra Albarado-Ibañez1; Marcia Hiriart2; Alejandro Frank Hoeflich3; Julian Torres-Jacome4
1 Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla and C3, UNAM; 2 Instituto de Fisiologia Celular, UNAM; 3 Centro de Ciencias de la Complejidad; 4 Instituto de Fisiologia
Resumo
In the mammals of heart rate depend on the production and conduction action potential cardiac with origin in pacemaker and any electrical changes could be produced sudden arrhythmias in the heart. The current evidence suggests that the rats with metabolic syndrome presented changes in the sino atrial node. However, is not relates the alteration produces by metabolic syndrome and rhythm cardiac such as the changes only related to vascular injury. In this study shows the existence of this relationship. We induced metabolic syndrome in young Wistar rats administering 20% sucrose in the drinking water. Ten and twenty eight weeks later, the rats were anesthetized and the electrocardiogram recorded, disclosed the heart rate decline from 237 bpm in control at 198 bpm in metabolic syndrome. The conventional microelectrodes technics showed that the production, morphology and propagated of action potential in sino atrial node was inadequate. The time series of RR and action potential intervals these data showed a decreased ability to regulate hear rate.
Palavras-chave: Nonlinear Dynamics and Complex Systems; System Biology; Time Series Analysis ; Pacemaker