STATE ESTIMATION PROBLEM IN HYPERTHERMIA TREATMENT OF CANCER INDUCED BY NEAR-INFRARED DIODE LASER HEATING
BERNARD LAMIEN1; HELCIO RANGEL BARRETO ORLANDE1; GUILLERMO ENRIQUE ELIÇABE2
1 PEM/COPPE/UFRJ; 2 INTEMA, University do Mar del Plata and National Research Council(CONICET), Argentina
doi:10.20906/CPS/COB-2015-2493
Resumo
In this paper, the hyperthermia treatment of cancer induced by near-infrared laser light is formulated as a state estimation problem and solved with particle filters. Although the hyperthermia treatment of cancer has been addressed in the literature by different computational methods, these usually involved deterministic analyses. On the other hand, state space representation of the problem in the Bayesian framework allows for the analyses of uncertainties present in the mathematical formulation of the problem, as well as in the measured data of observable variables that might be eventually available. A physical problem involving the irradiation with a laser in the near infrared range of a nonhomogeneous cylindrical medium representing a soft-tissue phantom containing a tumor. The region representing the tumor is assumed to be loaded with plasmonic nanoparticles in order to enhance the hyperthermia effects and to limit such effects to the tumor. The laser tissue interaction is modelled as a coupled radiation-bioheat transfer problem. For the solution of the inverse problem, local temperature measurements are assumed available.
Palavras-chave: State estimation problem; Particle filter; Hyperthermia; cancer; Nanoparticles