Bone remodeling based on cells activities and pharmacokinetics
Miguel Tobias Bahia1; Mildred Ballin Hecke2; Emilio Graciliano Ferreira Mercuri2
1 Instituto Federal de Santa Catarina; 2 Universidade Federal do Paraná
doi:10.20906/CPS/CILAMCE2017-0867
Resumo
This work presents a pharmacokinetic model for antiresorptive agents integrated to a bone remodeling model based on the behavior of bone cells populations. The proposed pharmacokinetic model describes the time course of drug in bone and is physiologically based (PBPK). The bone tissue is modeled by two compartments: one metabolically active, where the remodeling process acts, and another metabolically inactive, which does not undergo remodeling. The simulation of bone remodeling is developed through a dynamic model of bone cells populations in which the temporal evolution of cells like osteoblasts, osteoclasts and the bone volume is governed by a system of differential equations. The system is solved by the 4th order Runge-Kutta method and all procedures were implemented in Matlab. Preliminary results indicate that the model is able to reproduce the expected action of antiresorptive agents on the temporal evolution of bone cells populations. According to the drug dose, route and frequency of administration, the procedure implemented allows to adjust the bone remodeling process.
Palavras-chave: Bone remodeling; Pharmacokinetics; Bone cells; Mathematical modeling